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Testosterone Cypionate is simply Testosterone with the Cypionate ester bound to the Testosterone chemical structure. ‘Cypionate’ is Cypionic acid, but once bound to Testosterone it is known in chemistry as an ester bond. When Testosterone Cypionate enters the body, enzymes will bind to the molecule and break down the bond between the ester and the Testosterone hormone, which takes some time depending on the size of the ester in question. Esters such as Cypionate, Enanthate, Decanoate, Undecylenate and so forth all possess longer half-lives than the smaller and shorter esters such as Propionate, Phenylpropionate, Acetate, etc. The process of enzymes breaking down and separating the ester from the Testosterone molecule results in the slower drug release profile. Pure Testosterone base with no ester bonded to it has a half-life of approximately 2 – 4 hours. With a Cypionate ester attached to it, the half-life is now extended to 12-14 days.
Where side effects are concerned, Testosterone Cypionate could be described as being moderate. It is often compared to its almost identical brother, Testosterone Enanthate. Cypionate has a longer half-life due to its longer fatty-acid ester chain.
Potential estrogenic side effects include the following: water retention and bloat, increased blood pressure (water retention), increased fat gain/retention, and gynecomastia.
Testosterone Cypionate users are also prone to androgenic side effects. Testosterone does undergo a reduction to Dihydrotestosterone (DHT) in the body which may result in the following: increase in oily skin and acne (sebum secretion), body and facial hair growth, and risk of male pattern baldness if one is predisposed to it.
Testosterone Cypionate has been found in studies not to be hepatotoxic (liver toxic), even when taken in extreme doses.
As Testosterone does impose suppression and shutdown of the hypothalamic testicular pituitary axis (HPTA) during a cycle which causes the body to stop manufacturing its own natural endogenous Testosterone.
Beginner dosages range from around 300 – 500mg weekly; Intermediate 500 – 750mg per week, and advanced as high as 1,000mg or more per week.
Water retention: Yes, high
High blood pressure: Yes
Liver toxic: Low
Aromatization: Yes, high
DHT Conversion: Yes, high
Decreased HPTA function: Yes, severe