Sibutramine

Dosage

One 30mg tablet per day every morning directly after breakfast. Sibutramine causes insomnia. Therefore, it should not be used at night.

Sibutralean Slim tablets are manufactured as a big tablet with a breaker in the middle. As a result, we highly recommend that new users start with 1/2 tablet and then work their way up to a full tablet. Sibutralean has been known for causing severe increases in heart rate. In addition it also causes feelings of anxiety. If you are not use to these kinds of side effects it is recommended that you start on 1/2 tab. 

Action

Sibutramine hydrochloride is a selective serotonin and noradrenaline re-uptake inhibitor. Obesity management is the main medical use of sibutramine. This is not a rapid acting drug. In other words it works rather slow and in a safe manner. This leads to a steady reduction in fat mass. Longer-term results can be maintained . This drug is most effective in conjunction with a low calorie diet and training program. 

Sibutralean reduces body fat via two very distinct and effective mechanisms. Firstly, it suppresses the appetite. Studies have shown people decrease their calorie intake with as much as 1300 calories a day. Secondly, Sibutralean stimulates metabolism and daily caloric expenditure. A single tablet of 30 mg sibutramine has shown an increase in basal metabolic rate by up to 30%. This increase in metabolic rate usually lasts up to six hours from taking the capsule.

Sibutramine has a thermogenic action that happens in the adrenergic system. This happens mainly through the indirect support of beta 3-receptor activation. With subutralen we mainly see strong increases in brown adipose tissue thermogenesis (BAT). This increases the body temperature by 0.5 to 1 degree Celsius. As soon as the body temperature increases it is a clear indication that thermogenesis has been triggered. This means that burning is now taking place. 

Clinical trials have shown that sibutramine works remarkably well with obese patients. The trials found that sibutramine also had significant improvements in serum triglyceride and HDL cholesterol levels. Patients entered into the clinical trials were obese. As a result their HDL cholesterol levels were extremely high when they started the clinical trials. For someone who is not obese the improvements in serum triglyceride and HDL cholesterol levels might not be as significant. 

Side Effects

The most common side effect with sibutramine is an increase in blood pressure. For this reason patients with high blood pressure and cardiovascular problems should not be using this product. Other common side effects include dry mouth, sleeplessness, irritability, back pain, stomach upset and constipation. The side effects Sibutramine causes usually subsides in the patient as they becomes accustomed to usage. Patients who are using any form of antidepressant should also not use this product. The drug interactions between sibutramine hydrochloride and antidepressants have shown to be a very negative one. 

Water Intake

After taking the 30 mg tablet of sibutramine in the morning you will get instantly very thirsty. Consequently, make sure you consume as much water as possible when this thirst sets in. Some people fight this thirst. This reduces the positive effects of sibutramine. As you increase your water intake sibutramine better activated. Fat burning results are more increased. Fighting the thirst without water consumption decreases the appetite suppressing characteristics. People who consumed a lot of water get better results. Therefore, without water uptake you get very hungry late afternoon. When the product wears off  you then defeat the object by consuming large amounts of food. With the increase of water late afternoon hunger is not an issue.

Sibutramine affects chemicals in the brain that affect weight maintenance.

Sibutramine is used together with diet and exercise to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.

Sibutramine may also be used for other purposes not listed in this medication guide.

Do not use sibutramine if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use sibutramine before the MAO inhibitor has cleared from your body.

You should not take sibutramine if you are allergic to it, or if you have severe or uncontrolled high blood pressure, an eating disorder (anorexia or bulimia), if you are taking stimulant diet pills, or if you have a history of coronary artery disease, stroke, or heart disease.

Before taking sibutramine, tell your doctor if you have glaucoma, high blood pressure, liver or kidney disease, depression, underactive thyroid, seizures, a bleeding disorder, a history of gallstones, or if you are older than 65 or younger than 16.

Tell your doctor about all prescription and over-the-counter medications you use, especially antidepressants, cold or allergy medication, narcotic pain medicine, or migraine headache medicines.

Tell your doctor if you do not lose at least 4 pounds after taking the medication for 4 weeks along with a low calorie diet.

Do not use sibutramine if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use sibutramine before the MAO inhibitor has cleared from your body.

You should not take this medication if you are allergic to sibutramine, or if you have:

• severe or uncontrolled hypertension (high blood pressure);
• an eating disorder (anorexia or bulimia);
• a history of coronary artery disease (atherosclerosis);
• a history of heart disease (congestive heart failure, heart rhythm disorder);
• a history of heart attack or stroke; or
• if you are taking stimulant diet pills.

If you have any of these other conditions, you may need a sibutramine dose adjustment or special tests:

• glaucoma;
• high blood pressure;
• liver disease;
• kidney disease;
• depression;
• underactive thyroid;
• epilepsy or seizure disorder;
• a bleeding or blood clotting disorder;
• a history of gallstones; or
• if you are older than 65 or younger than 16.

FDA pregnancy category C. It is not known whether sibutramine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using sibutramine.

It is not known whether sibutramine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give this medication to anyone younger than 16 years old.